The results of laboratory researches, directed on improvement of technology of flotation beneficiation of copper-molibdenum ores from Kazhdaranskoe deposit have been presented. It is recommended to use AeroMX and Aeroflot reagents in the cycle of copper flotation with residual concentration of sodium sulphide not more than 0,07 % and at temperature of pulp as much as 25-27 °C.