Analysis of influence of substantial composition of pyrite ores on the principle of building of technological flotation schemes has been realized. It has been shown that usage of combination of Beraflot 3035 reagent and butyl xanthate allows to reduce pyrite extraction and redistribute generations of sphalerite with different flotation properties between finishing concentrates. Combination of collectors on the base of dithiophosphates and tionocarbamates allow to extract hard-flotated sphalerite in conditional concentrate just in the ore cycle.